Journal of Indian Society of Periodontology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 19  |  Issue : 1  |  Page : 14--17

Interleukin-17 and interleukin-18 levels in different stages of inflammatory periodontal disease


Muthugounder Nalanaswamy Chitrapriya, Suresh Ranga Rao, Vamsi Lavu 
 Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India

Correspondence Address:
Suresh Ranga Rao
Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, No. 1, Ramachandra Nagar, Porur, Chennai 600 116, Tamil Nadu
India

Context: Chronic periodontitis is an inflammatory condition of the tooth supporting structures. There is increasing evidence that the cytokines interleukin-17 (IL-17) and interleukin-18 (IL-18) play a role in progression of chronic periodontitis. Aim: The objective of this study was to compare the levels of the cytokines IL-17 and IL-18 in gingival tissue extracts from individuals with healthy gingiva, chronic gingivitis, and mild chronic periodontitis. Settings and Design: The study was performed in a hospital-based population with an experimental design. Materials and Methods: A total of 69 individuals (n = 23 per group) were recruited for the study. Group 1 included 23 individuals with healthy gingiva and Group 2 included 23 chronic gingivitis patients and Group 3 included 23 patients with mild chronic periodontitis. Gingival tissues were collected during surgical procedures and levels of IL-17 and IL-18 were determined using enzyme-linked immunosorbent assay. Statistical Analysis: Intergroup comparison was done by posthoc Tukey«SQ»s test. Results: The gingival tissue concentration of IL-17 was found to be highest in Group 2 (415.19 ± 76.84 pg/mg) followed by Group 3 (193.77 ± 37.32 pg/mg) and Group 1 (20.49 ± 6.05 pg/mg). Concentrations of IL-18 were significantly higher (P < 0.01) in Group 2 (1479.42 ± 330.33 pg/mg) when compared with Group 1 (385.18 ± 71.26 pg/mg) and Group 3 (330.24 ± 48.56 pg/mg). Conclusion: There appears to be considerable variation of IL-17 and IL-18 levels in gingival tissue during periodontal health and disease.


How to cite this article:
Chitrapriya MN, Rao SR, Lavu V. Interleukin-17 and interleukin-18 levels in different stages of inflammatory periodontal disease.J Indian Soc Periodontol 2015;19:14-17


How to cite this URL:
Chitrapriya MN, Rao SR, Lavu V. Interleukin-17 and interleukin-18 levels in different stages of inflammatory periodontal disease. J Indian Soc Periodontol [serial online] 2015 [cited 2022 Jun 28 ];19:14-17
Available from: https://www.jisponline.com/article.asp?issn=0972-124X;year=2015;volume=19;issue=1;spage=14;epage=17;aulast=Chitrapriya;type=0