Journal of Indian Society of Periodontology

ORIGINAL ARTICLE
Year
: 2008  |  Volume : 12  |  Issue : 2  |  Page : 41--44

Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis


Neetha Shetty1, Biju Thomas2, Amita Ramesh2 
1 Department of Periodontics, MCODS, Mangalore., India
2 Department of Periodontics, ABSMIDS, Mangalore, India

Correspondence Address:
Neetha Shetty
Department of Periodontics, MCODS, Mangalore - 575 001.
India

Background : Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes. Aim: The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis. Materials and Methods: Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonas gingivalis by diabetic PMNs were evaluated relative to healthy and matched controls. Results: These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01).


How to cite this article:
Shetty N, Thomas B, Ramesh A. Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis.J Indian Soc Periodontol 2008;12:41-44


How to cite this URL:
Shetty N, Thomas B, Ramesh A. Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis. J Indian Soc Periodontol [serial online] 2008 [cited 2021 Jul 23 ];12:41-44
Available from: https://www.jisponline.com/article.asp?issn=0972-124X;year=2008;volume=12;issue=2;spage=41;epage=44;aulast=Shetty;type=0