| CASE REPORT |
|
| Year : 2020 | Volume
: 24
| Issue : 3 | Page : 280-283 |
|
|
Son of Sevenless-1 genetic status in an Indian family with nonsyndromic hereditary gingival fibromatosis
Nitya Kala1, Harikrishnan Prasad2, Premalatha Babu3, Srinivasan Poovan Kirubanidhi Kennedy Babu4
1 Department of Periodontology, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India
2 Department of Oral Pathology and Microbiology, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India
3 Department of Oral Pathology and Microbiology, Mahatma Gandhi Post Graduate Institute of Dental Sciences, Pondicherry, India
4 Department of Periodontology, Mahatma Gandhi Post Graduate Institute of Dental Sciences, Pondicherry, India
Correspondence Address:
Nitya Kala
Department of Periodontology, KSR Institute of Dental Science and Research, KSR Kalvi Nagar, Thokkavadi, Tiruchengode - 637 215, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jisp.jisp_329_19
|
|
|
Hereditary gingival fibromatosis (HGF) is a rare condition affecting the gingiva and may or may not be a clinical feature of other syndromes. It has been classified as a nondental biofilm-induced gingival disease. The pathogenesis of this condition has been poorly understood till date. Although different genetic mutations have been implicated to play a role, there is considerable interest on an addition mutation of Son of Sevenless-1 (SOS-1) gene. We report a case of a 27-year-old male patient who came to us with the complaint of enlarged gums of several years' duration. There were other members in his family who were similarly affected. After the clinical diagnosis of HGF was confirmed, the patient and his available family members were subjected to a genetic analysis for identification of mutation in SOS-1 gene, which turned out to be negative. The patient was treated with nonsurgical periodontal therapy and is under regular follow-up. To the best of our knowledge, this is the first study to assess SOS-1 mutation in an Indian family.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
| 
