Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 391-393

Multiple myeloma presenting as gingival hyperplasia

1 Department of Periodontology and Oral Implantology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India
2 Department of Periodontology and Oral Implantology, Adesh Institute of Dental Sciences, Bhatinda, Punjab, India
3 Department of Prosthodontics, Government Dental College and Hospital, Patiala, Punjab, India

Correspondence Address:
Gaurav Kansal
115/2, Anand Nagar Moga, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.115652

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Multiple myeloma is a malignant neoplasm that is characterized by a monoclonal proliferation of plasma cells. Oral and maxillofacial manifestations as an initial sign or symptom of multiple myeloma are rare. A 58-year-old male patient presented with generalized gingival enlargement for last 6 months. Based on clinical presentation, a diagnosis of gingival hyperplasia was made. After Phase I therapy, excisional biopsy was taken in anterior mandibular region and excised tissue was sent for histopathological examination. The histopathology report revealed a lining of stratified squamous epithelium with foci of ulceration. The subepithelial zone showed infiltration by sheets of mainly binucleate and multinucleate plasma cells, few cells being less differentiated. Rounded cytoplasmic inclusion bodies were identified in many of these cells. After a series of clinical investigations, a case of "multiple myeloma" was diagnosed. Patient presenting with generalized gingival hyperplasia should be worked up for systemic disease like multiple myeloma.

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