Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2010  |  Volume : 14  |  Issue : 1  |  Page : 40-45

Evaluation of an aminobisphosphonate (alendronate) in the management of periodontal osseous defects

1 Assistant Professor, Department of Periodontics, KLE Institute of Dental Sciences and Research Centre, Yeshwanthpur Suburb, Bangalore-560 022, Karnataka State, India
2 Professor and Head, Department of Periodontics, Farooquia Dental College and Hospital, Umer Khayyam Road, Tilak Nagar, Mysore - 570 021, Karnataka State, India

Correspondence Address:
H R Veena
Department of Periodontics, KLE Institute of Dental Sciences and Research Centre, Yeshwanthpur Suburb, Bangalore-560 022 Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.65438

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Background and Objectives: Alendronate, an aminobisphosphonate, is capable of inhibiting periodontitis associated osteoclastic activity and hence is effective in protecting the alveolar bone in periodontitis. In the present study, we explored the efficacy of local delivery of alendronate on the alveolar bone following mucoperiosteal flap surgery. This is the first study to use polymer impregnated gel based delivery of alendronate. Materials and Methods: A total of 15 patients with chronic periodontitis in the age group of 35 - 55 years, of both sexes, with pocket depth of ≥ 5mm and radiographic evidence of identical osseous defects in the mandibular molar region bilaterally were included in this prospective study. A gel based drug delivery system of Alendronate was formulated. Following surgical flap debridement, 0.1 ml alendronate gel and 0.1 ml placebo gel was placed at the experimental and control sites respectively. Clinical and radiographic parameters were recorded at baseline, three months and six months post surgery. Results: Alendronate was more effective in improving clinical and radiographic parameters compared to placebo. Interpretation and Conclusion: Alendronate is effective in the management of periodontitis associated bone loss. Gel based local delivery of the drug addresses the critical concern of exposing the patient to adverse effects of systemic administration.

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