Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2009  |  Volume : 13  |  Issue : 2  |  Page : 69-74

Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis

Department of Periodontics, Meenakshi Ammal Dental College, Chennai, India

Correspondence Address:
Dhruva Kumar Gani
Narayana Dental College, Nellore, Andhra Pradesh, Pincode - 524001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.55840

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Aims and Objectives: The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals. Materials and Methods: A total of 42 individuals, both males and females above the age of 30 years, were included in the study. Healthy controls (Group I, n = 14), chronic localized periodontitis (Group II, n = 14), and chronic generalized periodontitis (Group III, n = 14), all without any medical disorder, were recruited. Peripheral blood samples were taken and C-reactive protein (CRP) levels were estimated in the serum samples by using the Particle-Enhanced Turbidimetric Immunoassay (PETIA) technique. Serum samples of Interleukin-6 (IL-6) were assayed by using the Chemiluminescent Immunoassay (IMMULITE) technique. Results: When mean CRP levels were compared between the groups, group III showed statistical significance when compared to group I (P = 0.04). Group III had a higher median IL-6 level (6.35 pg/mL) than Group II (< 5.0 pg/ mL) and group I (< 5.0 pg/mL). Differences in median values of IL-6 were not statistically significant in any group (P = 0.29). Conclusion: Periodontitis results in higher systemic levels of CRP and IL-6. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events.

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