Journal of Indian Society of Periodontology
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Year : 2009  |  Volume : 13  |  Issue : 1  |  Page : 50-54 Table of Contents   

Platelet-rich-fibrin: A novel root coverage approach

Department of Periodontics, Meenakshi Ammal Dental College, Madhuravoyal, Chennai - 600 095, India

Date of Submission30-Nov-2008
Date of Acceptance11-Apr-2009
Date of Web Publication5-Jun-2009

Correspondence Address:
K Anilkumar
Sr. Lecturer, Department of Periodontics,Meenakshi Ammal Dental College,Madhuravoyal,Chennai - 600 095
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.51897

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Treatment of gingival recession has become an important therapeutic issue due to increasing cosmetic demand. Multiple surgical procedures have been developed to obtain predictable esthetic root coverage. More specifically, after periodontal regenerative surgery, the aim is to achieve complete wound healing and regeneration of the periodontal unit. A recent innovation in dentistry is the preparation and use of platelet-rich plasma (PRP), a concentrated suspension of the growth factors, found in platelets. These growth factors are involved in wound healing and postulated as promoters of tissue regeneration. This paper reports the use of PRF membrane for root coverage on the labial surfaces of the mandibular anterior teeth. This was accomplished using laterally displaced flap technique with platelet rich fibrin (PRF) membrane at the recipient site.

Keywords: Plasma rich-derivative (PRF membrane), recession, regeneration, repair

How to cite this article:
Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijayalakshmi R, Pameela E. Platelet-rich-fibrin: A novel root coverage approach. J Indian Soc Periodontol 2009;13:50-4

How to cite this URL:
Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijayalakshmi R, Pameela E. Platelet-rich-fibrin: A novel root coverage approach. J Indian Soc Periodontol [serial online] 2009 [cited 2022 Aug 12];13:50-4. Available from:

   Introduction Top

Periodontal plastic surgery procedures aimed at coverage of exposed root surfaces have evolved into routine treatment modalities. The main indications for root coverage procedures are esthetic concern, root hypersensitivity, prevention or management of root caries and cervical abrasion, enhancement of restorative outcomes, and facilitation of plaque control efforts. Among them, traumatic tooth brushing and tooth mal-positioning have been related most frequently to gingival recession. [1] The goal of periodontal therapy is to protect and maintain the patient's natural dentition over his or her lifetime for optimal comfort, function and esthetic appearance. [2],[3] Therefore, marginal gingival recession should not be viewed as merely a soft tissue defect, but rather as the destruction of both soft and hard tissue.

Since mid 20 th century, different techniques have been developed to cover denuded roots. Free autogenous grafts and pedicle grafts including rotational flaps, advanced flaps, and semilunar flaps have been advocated. Combination grafts with either autogenous grafts or allograft and with GTR membranes were developed later to correct mucogingival defects. [4]

A recent innovation in dentistry is the preparation and use of platelet-rich fibrin (PRF), a concentrated suspension of the growth factors found in platelets. These growth factors are involved in wound healing and are postulated as promoters of tissue regeneration. [5] Platelet concentrate contains PDGF, TGF and many other unidentified growth factors that modulate and upregulate one growth factors function in the presence of second or third growth factor. [6] This specific feature influenced the decision to use platelet concentrates as the test material of choice in this case report. In the case described in this article, platelet rich derivative (PRF membrane) was combined with a laterally positioned flap for root coverage.

Clinical Presentation

A 19-year-old male was referred by his general dentist for an evaluation of recession over the buccal prominence of the mandibular left incisor close to the mucogingival junction. At the time of presentation, clinical examination revealed 7 mm of clinical attachment loss. The distance between the cemento-enamel junction and gingival margin was 5 mm and the distance between the gingival margin and the base of the pocket was 2 mm [Figure 1].

Presurgical therapy : The surgical procedure was explained to the patient and the informed consent obtained. Preparation of the patient included scaling and root planing of the entire dentition and oral hygiene instructions. The following parameters were recorded before and after surgery.

Probing pocket depth (PPD) : Gingival recession (GR), by measuring the distance between the cementoenameljunction (CEJ) to the free gingival margin.

PRF Preparation

The advantages of PRF over PRP are its simplified preparation and lack of biochemical handling of the blood. The required quantity of blood is drawn in 10 ml test tubes without an anticoagulant and centrifuged immediately. Blood is centrifuged using a tabletop centrifuge (REMY Laboratories) for 12 minutes at 2,700 rpm. [7]

The resultant product consists of the following three layers [Figure 2]:

  • Top most layer consisting of acellular PPP
  • PRF clot in the middle
  • RBCs at the bottom
Because of the absence of an anticoagulant, blood begins to coagulate as soon as it comes in contact with the glass surface. Therefore, for successful preparation of PRF, speedy blood collection and immediate centrifugation before the clotting cascade is initiated, is absolutely essential. PRF can be obtained in the form of a membrane by squeezing out the fluids in the fibrin clot [7] [Figure 3].

Surgical procedure : The use of laterally repositioned flap to cover areas with localized recession was introduced by Grupe and Warren in 1956. This technique involved the reflection of a full thickness flap/partial thickness flap at the donor area adjacent to the defect and subsequent displacement of this flap to cover the exposed root surface.

After proper isolation of the surgical field, the operative sites were anaesthetized using two per cent xylocainehydrochloride with adrenaline ( 1:200000 ). A reverse bevel 'V' shape incision was made along the soft tissue margin of the recipient site in order to remove the epithelium around the root surface [Figure 4]. Then the donor site was prepared by giving a vertical incision from the gingival margin to outline the flap adjacent to the recipient site and a full thickness flap was elevated [Figure 5]. The PRF membrane was placed over the denuded roots and stabilized [Figure 6]. The flap was then slided to completely cover the membrane and secured using sling sutures [Figure 7].

Post operative care : Patients were placed on 0.12% chlorhexidine digluconate mouthrinse for four weeks. Systemic antibiotics were prescribed and advised to follow routine post-operative periodontal mucogingival instructions, with minor modifications. They were warned to avoid pulling on their lips to observe the surgical site. The surgical site was repacked after 1 week. Both dressings and sutures were removed 10 days after surgery [Figure 8].

Healing : Post-operative follow up was done for one month [Figure 9]. In this case, there was no post-operative complication and healing was satisfactory. The patients did not have any post-operative morbidity. Complete coverage was achieved six months after the procedure, with excellent tissue contour and color [Figure 10].

   Discussion Top

The ultimate goal of any therapeutic intervention aimed at root coverage should be to restore the tissue margin at the cementoenamel junction (CEJ) and to achieve an attachment of the tissues to the root surface so that a normal healthy gingival sulcus with no bleeding on probing and a minimal probing depth is present. [8] Patients have, recently, become more conscious of dental esthetics and accordingly have been demanding precision treatment of their exposed root surfaces.

Various surgical procedures have been described to treat gingival recessions, but these have been demonstrated to heal with a long junctional epithelium, and regeneration has been observed only in the most apical portion of the lesion. Although the bilaminar technique using subepithelial connective tissue grafts still holds the most promising results in root coverage, histological studies show unpredictable healing. The use of PRF membrane in our case report to attain root coverage may alleviate the need for donor site procurement of connective tissue. This has encouraged investigations of a more regenerative nature. The use of enamel matrix protein is one trend aiming at periodontal regeneration and root coverage. [9] The use of barrier membranes is another trend. [10]

In general, a recent innovation in dentistry has been the preparation and use of platelet-rich fibrin (PRF), a concentrated suspension of the growth factors found in platelets. These growth factors are involved in wound healing and postulated as promoters of tissue regeneration. It is both nontoxic and nonimmunoreactive. [11] Early studies have focused on PRP application to bone graft material, showing that it leads to earlier bone regeneration and soft tissue healing. [12] PRP can also be infused into resorbable barrier membranes to retard epithelial migration, as well as to provide localized growth factors to accelerate hard and soft tissue maturation. [13]

PRP may be obtained from autologous blood by the use of plasmaphoresis. PRF was first developed in France by Choukroun et al . [14] This second generation platelet concentrate eliminated the risk associated with the use of bovine thrombin. Placement of PRF membrane in recession defects can be used to restore the functional properties of the labial gingiva of the mandibular anterior teeth by repairing gingival defects and re-establishing the continuity and integrity of the zone of keratinized gingiva.

A report of clinical trails comparing the growth factors content of PRF and PRP was presented by Dohan and Diss at the second international Symposium on growth factors held in May 2005. [15] Combining the growth factors has been shown to accelerate bone repair and promote fibroblast proliferation, and increase tissue vascularity, rate of collagen formation, mitosis of mesenchymal stem cells and endothelial cells, as well as osteoblasts, playing key roles in the rate and extent of bone formation. This activity, together with increased vessel ingrowth, is mediated by PDGF and TGF. Because of all of these powerful effects on tissue regeneration, a growing number of human clinical studies have detailed the use of growth factors in reconstructive oral and maxillofacial surgery, periodontal surgery, implants, and sinus grafting. [16]

PRF membrane used in this case report has the advantage of the absence of an anticoagulant, blood begins to coagulate as soon as it comes in contact with the glass surface. Therefore, for successful preparation of PRF, speedy blood collection and immediate centrifugation, before the clotting cascade is initiated, is absolutely essential.

   Conclusion Top

Soft tissue maintenance is the primary line of defense in protecting the tissue from bacterial infection. Although the growth factors and the mechanisms involved are still poorly understood, the ease of applying PRF in the dental clinic and its beneficial outcomes, including reduction of bleeding and rapid healing, holds promise for further procedures. More well designed and properly controlled studies are needed to provide solid evidence of PRF's capacity for and impact on wound healing, soft-tissue reconstruction and (in combination with bone grafts) augmentation procedures, especially in periodontal therapy.

   References Top

1.Gorman WJ. Prevalence and etiology of gingival recession. J Periodontol 1976;38:316-22.  Back to cited text no. 1    
2.Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy. J Periodontol 1976;47:261-6.   Back to cited text no. 2    
3.Carranza FA, McLain PK, Schallhorn RG. Regenerative osseous surgery. Clinical Periodontology. 9th ed. 2002. p. 804-24.  Back to cited text no. 3    
4.Pin Prato GP, Tinti C, Vincenz G, Magnani C, Cortellini P, Clauser C. Guided tissue regeneration versus mucogingival surgery in the treatment of human buccal gingival recession. J Periodontol 1992;63:919-28.  Back to cited text no. 4    
5.Tφzüm TF, Demiralp B. Platelet-Rich Plasma: A Promising Innovation in Dentistry. J Can Dent Assoc 2003;69:664.   Back to cited text no. 5    
6.Griffin TJ, Cheung WS. Treatment of gingival recession with a platelet concentrate graft: A report of two cases. Int J Periodont Restorat Dent 2004;24:589-95.  Back to cited text no. 6    
7.Sunitha Raja, Munirathnam Naidu E. Platelet rich fibrin: Evolution of a second generation platelet concentrate. Indian J Dent Res 2008;19:42-6.  Back to cited text no. 7    
8.Guptha R, Pandit N, Sharma M. Clinical evaluation of a bioabsorbable membrane (polyglactin 910) in the treatment of miller type II gingival recession. Int J Periodont Restorat Dent 2006;26:271-7.  Back to cited text no. 8    
9.Hagewald S, Spahr A, Rompola E, Haller B, Bernimoulin JP. Comparative study of emdogain and coronally advanced flap technique in the treatment of human gingival recessions: A prospective controlled clinical study. J Clin Periodontol 2002;29:35-41.  Back to cited text no. 9    
10.Muller HP, Stahl M, Eger T. Root coverage employing an envelope technique or guided tissue regeneration with a bioabsorbable membrane. J Periodontol 1999;70:743-51.  Back to cited text no. 10    
11.Gonshor A. Technique for producing platelet-rich plasma and platelet concentrate: Background and process. Int J Periodont Restorat Dent 2002;22:547-57.  Back to cited text no. 11    
12.Marx RE, Carlson ER, Eichstaedt RM, Schirnmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma. Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46.  Back to cited text no. 12    
13.Garg AK, Gargenese D, Peace I. Using platelet-rich plasma to develop an autologous membrane for growth factor delivery in dental implant therapy. Dent Implantol Update 2000;11:41-3.  Back to cited text no. 13    
14.Choukroun J, Dohan DM, Simonpieri A, Schoeffler C, Dohan SL, Dohan AJ, et al . Platelet rich fibrin (PRF): A second generation platelet concentrate: Part V: Histologic effects of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral med Oral Patho Oral Radio Endod 2006;101:E299-303.  Back to cited text no. 14    
15.Dohan.D and Diss.A DM. Platelet rich plasma versus platelet rich fibrin (PRF): comparison of growth factor continent and osteoblast proliferation and differentiation in the cell culture. In report of second international symposium on growth factors (SyFac2005). Implantodontie 2005;14:116-25.  Back to cited text no. 15    
16.Lozada JL, Caplanis N, Proussaefs P, Willardsen J, Kammeyer G. Platelet-rich plasma application in sinus graft surgery: Part I -Background and processing techniques. J Oral Implantol 2001;27:38-42.  Back to cited text no. 16    


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10]

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