Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2008  |  Volume : 12  |  Issue : 2  |  Page : 41-44

Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis

1 Department of Periodontics, MCODS, Mangalore., India
2 Department of Periodontics, ABSMIDS, Mangalore, India

Correspondence Address:
Neetha Shetty
Department of Periodontics, MCODS, Mangalore - 575 001.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.44089

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Background : Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes. Aim: The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis. Materials and Methods: Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonas gingivalis by diabetic PMNs were evaluated relative to healthy and matched controls. Results: These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01).

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