Journal of Indian Society of Periodontology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 23  |  Issue : 2  |  Page : 119--123

Hydrogen peroxide masks the bitterness of chlorhexidine mouthwash without affecting its antibacterial activity


Widhunya Mathurasai1, Panida Thanyasrisung2, Sireerat Sooampon1, Benjar Issaranggun Na Ayuthaya1 
1 Department of Pharmacology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
2 Department of Microbiology and RU on Oral Microbiology and Immunology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

Correspondence Address:
Dr. Benjar Issaranggun Na Ayuthaya
Department of Pharmacology, Faculty of Dentistry, Chulalongkorn University, 34 Henri Dunant Road, Pathumwan, Bangkok 10330
Thailand

Background: Chlorhexidine (CHX) is an antiseptic mouthwash widely used as the gold standard for inhibiting plaque formation. However, the bitter taste of CHX limits patient compliance. We developed a 0.12% CHX and 1.5% hydrogen peroxide (H2O2) mouthwash that masked the bitter taste of CHX. This study evaluated the antibacterial activity and subject satisfaction of the developed mouthwash. Materials and Methods: Three mouthwashes were used as follows: (1) a commercial 0.12% CHX mouthwash, (2) a prepared 0.12% CHX mouthwash containing 1.5% H2O2, and (3) a prepared 0.12% CHX mouthwash. A disc diffusion assay was performed to determine the antibacterial activity of each mouthwash against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. To assess subject satisfaction with each mouthwash, a satisfaction questionnaire was completed immediately after rinsing with each mouthwash. Results: The antibacterial activities of the three mouthwashes were similar. Moreover, the questionnaire results revealed that the level of satisfaction was significantly higher for the 0.12% CHX/1.5% H2O2 mouthwash compared with the other mouthwashes. Conclusion: The 0.12% CHX/1.5% H2O2 mouthwash revealed a similar antibacterial activity as the CHX standard against periodontal disease pathogens. In addition, the subjects were more satisfied with the new formula compared with 0.12% CHX alone. These data suggest that the 0.12% CHX/1.5% H2O2 formulation is an alternative antibacterial mouthwash to avoid the unpleasant CHX side effects.


How to cite this article:
Mathurasai W, Thanyasrisung P, Sooampon S, Ayuthaya BI. Hydrogen peroxide masks the bitterness of chlorhexidine mouthwash without affecting its antibacterial activity.J Indian Soc Periodontol 2019;23:119-123


How to cite this URL:
Mathurasai W, Thanyasrisung P, Sooampon S, Ayuthaya BI. Hydrogen peroxide masks the bitterness of chlorhexidine mouthwash without affecting its antibacterial activity. J Indian Soc Periodontol [serial online] 2019 [cited 2020 Apr 4 ];23:119-123
Available from: http://www.jisponline.com/article.asp?issn=0972-124X;year=2019;volume=23;issue=2;spage=119;epage=123;aulast=Mathurasai;type=0