Journal of Indian Society of Periodontology

SHORT COMMUNICATION
Year
: 2012  |  Volume : 16  |  Issue : 4  |  Page : 620--622

A comparative evaluation of whole blood total antioxidant capacity using a novel nitroblue tetrazolium reduction test in patients with periodontitis and healthy subjects: A randomized, controlled trial


Kranti Konuganti, Hema Seshan, Sameer Zope, Wilma Delphine Silvia 
 Department of Periodontics, M. S. Ramaiah Dental College, Bangalore, Karnataka, India

Correspondence Address:
Kranti Konuganti
Department of Periodontics, M.S Ramaiah Dental College, MSRIT Post, MSR Nagar, Bangalore - 560 054
India

The investigation of disease-related oxidant-antioxidant imbalance is difficult due to the limited availability of specific biomarkers of oxidative stress, and the fact that measurement of individual antioxidant may give misleading picture because antioxidants work in concert through chain breaking reactions. Therefore, analysis of total antioxidant capacity may be the most relevant investigation. As the total blood is continuously exposed to oxidative stress, the aim of the current study was to investigate total blood antioxidant capacity in healthy and periodontitis patients by using novel Nitroblue Tetrazolium reduction test. The study was conducted on 30 non-smoking volunteers with age ranging between 18-40 years. They were categorized into two groups; chronic periodontitis group and healthy group, respectively. Total antioxidant capacity in whole blood was assessed using Nitroblue Tetrazolium reduction test. Results of the present study has shown that the total antioxidant capacity in whole blood in patients with periodontitis was significantly (P<0.005) lower than in control subjects. The reduced total blood antioxidant status in periodontitis subjects warrants further investigation as it may provide a mechanistic link between periodontal disease and several other free radical-associated chronic inflammatory diseases.


How to cite this article:
Konuganti K, Seshan H, Zope S, Silvia WD. A comparative evaluation of whole blood total antioxidant capacity using a novel nitroblue tetrazolium reduction test in patients with periodontitis and healthy subjects: A randomized, controlled trial.J Indian Soc Periodontol 2012;16:620-622


How to cite this URL:
Konuganti K, Seshan H, Zope S, Silvia WD. A comparative evaluation of whole blood total antioxidant capacity using a novel nitroblue tetrazolium reduction test in patients with periodontitis and healthy subjects: A randomized, controlled trial. J Indian Soc Periodontol [serial online] 2012 [cited 2019 Oct 23 ];16:620-622
Available from: http://www.jisponline.com/article.asp?issn=0972-124X;year=2012;volume=16;issue=4;spage=620;epage=622;aulast=Konuganti;type=0