Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
Home | About JISP | Search | Accepted articles | Online Early | Current Issue | Archives | Instructions | SubmissionSubscribeLogin 
Users Online: 261  Home Print this page Email this page Small font size Default font size Increase font sizeWide layoutNarrow layoutFull screen layout
 
ORIGINAL ARTICLE
Ahead of Print

Interleukin-6, tumor necrosis factor-α, C-reactive protein, and hematological parameters in experimental periodontal disease after β-adrenergic blockade


1 Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba; Instituto de Biotecnologia, Programa de Pós-graduação em Genética e Bioquímica Universidade Federal de Uberlândia, Uberlândia, MG, Brazil
2 Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba; Unidade de Biociências, Centro Universitário de Mineiros, Mineiros, GO, Brazil
3 Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil
4 Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Campinas, SP, Brazil
5 Instituto de Biotecnologia, Programa de Pós-graduação em Genética e Bioquímica Universidade Federal de Uberlândia, Uberlândia, MG, Brazil

Correspondence Address:
Wellington Francisco Rodrigues,
Av. Tutunas, 490, Tutunas, 38057-200, Uberaba, MG
Brazil
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_77_19

Background: Changes in the levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) observed during periodontal disease were linked with vascular manifestations. Recent studies showed that the beta-blocker propranolol reduces the pathological parameters associated with certain molecules at sites of bone injury. Hence, in this study, we evaluated the activity of propranolol on hematological parameters and systemic concentrations of inflammatory proteins in a model of experimental periodontitis. Materials and Methods: Periodontal disease was induced in rats. After euthanasia, the number of inflammatory cells in each rat was quantified using histopathological assays. In addition, hematological parameters were quantitated using automated analysers, cytokine levels were determined using an enzyme-linked immunosorbent assay, and CRP levels were determined using a high-sensitivity immunoturbidimetric assay. Results: Low doses of propranolol suppressed the systemic production of CRP, TNF-α, and IL-6; however, the hematological parameters were not affected. Conclusions: β-adrenergic activation indirectly contributes to the pattern of systemic inflammatory molecules observed in periodontal disease. These molecules may initiate cardiovascular diseases as a consequence of periodontitis.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Rodrigues WF
    -  Miguel CB
    -  Lazo-Chica JE
    -  Trindade da Silva CA
    -  Vieira CU
    -  Clemente-Napimoga JT
    -  Freire Oliveira CJ
    -  Napimoga MH
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed32    
    PDF Downloaded5    

Recommend this journal