Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Management of phenytoin-induced gingival enlargement in a patient with antiphospholipid antibody syndrome: A rare case report

1 Department of Periodontics, Narsinhbhai Patel Dental College, Visnagar, Gujarat, India
2 Department of Oral Pathology, Mithila Minority Dental College, Darbhanga, Bihar, India
3 Department of Periodontics, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India

Correspondence Address:
Shilpa Sarvesh Urolagin,
Department of Periodontics, Narsinhbhai Patel Dental College, S. P. Sahakar Vidyadham, Kamana Crossing, Visnagar - 384 315, Gujarat
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Source of Support: None, Conflict of Interest: None

Antiphospholipid antibody (APLA) syndrome is a noninflammatory autoimmune disease, with innumerable clinical manifestations ranging from recurrent thrombosis and pregnancy morbidity to valvular lesions, transverse myelitis, thrombocytopenia, and hemolytic anemia. APLAs in antiphospholipid syndrome (APS) are well-known risk factors for cerebrovascular accidents. Stroke is the most common manifestation of APS in the central nervous system. Gingival enlargement is a known side effect of phenytoin which is an antiepileptic drug. This can have a significant effect on the quality of life as well as increasing the oral bacterial load by generating plaque retention sites. The management of gingival overgrowth seems to be directed at controlling gingival inflammation through a good oral hygiene regimen. Thus, this case report aims to describe the conservative management of phenytoin-induced gingival enlargement combined with inflammatory enlargement in a patient with APLA syndrome.

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