Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
Home | About JISP | Search | Accepted articles | Online Early | Current Issue | Archives | Instructions | SubmissionSubscribeLogin 
Users Online: 1672  Home Print this page Email this page Small font size Default font size Increase font sizeWide layoutNarrow layoutFull screen layout
ORIGINAL ARTICLE
Year : 2018  |  Volume : 22  |  Issue : 5  |  Page : 433-437

Evaluation of anti-inflammatory effect of chorion membrane in periodontal pocket therapy: A clinical and biochemical study


Department of Periodontics, KAHE's KLE V. K. Institute of Dental Sciences, KAHER (KLE University), Belagavi, Karnataka, India

Correspondence Address:
Shaila Kothiwale
Department of Periodontics, V. K. Institute of Dental Sciences, KLE Acedemy of Higher Education and Research, Belagavi - 590 010, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jisp.jisp_280_18

Rights and Permissions

Background: The aim of the study was to evaluate the anti-inflammatory effect of chorion as a barrier membrane in periodontal pocket therapy by assessing interleukin-11 (IL-11) level in gingival crevicular fluid (GCF). Materials and Methods: The study was a randomized, controlled, single-blind clinical trial with split-mouth design. In each patient, two sites in two quadrants were selected and randomly allocated in Group 1 (flap surgery) and Group 2 (flap surgery + chorion membrane placement). After Phase 1 therapy, clinical and biochemical parameters were recorded at baseline and at 4 weeks. Plaque index (PI), sulcus bleeding index (SBI), probing pocket depth (PPD), clinical attachment level (CAL), and IL-11 in GCF were assessed. GCF was collected using microcapillary tubes. IL-11 was assayed in GCF with ELISA kit (Genxbio®). Results: At baseline, the clinical and the biochemical parameters were similar in both the groups. Intragroup comparison revealed statistically significant decrease in all clinical and biochemical parameters in Group 1 (P < 0.001) and Group 2 (P < 0.001). Intergroup comparison showed statistically significant decrease in SBI (P = 0.004), PPD (P = 0.004), CAL (P = 0.013), and IL-11 (P = 0.006) in Group 2 compared to Group 1 at 4 weeks. However, PI did not show any statistically significant difference on intergroup comparison. Conclusion: Adjunctive use of chorion membrane in flap surgery provides an additive anti-inflammatory effect along with improvement in clinical outcomes enhancing the long-term prognosis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1258    
    Printed16    
    Emailed0    
    PDF Downloaded275    
    Comments [Add]    

Recommend this journal