Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2015  |  Volume : 19  |  Issue : 6  |  Page : 651-658

Evaluation of anorganic bovine-derived hydroxyapatite matrix/cell binding peptide as a bone graft material in the treatment of human periodontal infrabony defects: A clinico-radiographic study

1 Department of Periodontics, Al-Badar Dental College and Hospital, Gulbarga, Karnataka, India
2 Department of Periodontics, Sri Hassanamba Dental College, Hassan, Karnataka, India
3 Department of Periodontics, SDM Dental College and Hospital, Dharwad, Karnataka, India
4 Department of Preventive Dentistry, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia

Correspondence Address:
Ghousia Fatima
Department of Periodontics, Al-Badar Dental College and Hospital, H.No. 5-449/7B, Khaja Colony, Gulbarga - 585 104, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.164766

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Background: Various bone graft materials have been used in the treatment of periodontal defects. A synthetic bone substitute material composed of P-15 with anorganic bone mineral has been scantly studied. Hence, the present study was aimed to evaluate and compare the efficacy of anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) in human periodontal infrabony defects with that of open flap debridement (OFD) alone. Materials and Methods: A split-mouth, randomized controlled clinical study was designed to investigate the efficacy of ABM/P-15. In this clinical trial, 10 patients having bilateral periodontal infrabony defects were treated either with ABM/P-15 or OFD and followed for a period of 9 months. At baseline and at 9 months probing pocket depth (PPD), relative attachment level (RAL), depth of a defect, and radiographic bone level were measured; and compared between test and control sites. Results: A statistically significant reduction (P < 0.001) in PPD was observed in test sites compared to control sites. Both sites showed a gain in RAL without any significant difference. Similarly, the radiographic evaluation revealed significantly higher radiographic defect fill in test sites as compared to control sites (P < 0.001). Conclusion: ABM/P-15 bone graft material appears to be useful and beneficial in the treatment of human periodontal infrabony defects.

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