Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2014  |  Volume : 18  |  Issue : 4  |  Page : 447-450

Prevalence of human papilloma virus in marginal periodontium and its association with periodontitis: A cross sectional study

Department of Periodontology, Government Dental College Trivandrum in collaboration with Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India

Correspondence Address:
Anila Jacob
Vattaparampil House, Gandhi Nagar (P.O), Kottayam Dist, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-124X.138682

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Context: Bacterial pathogens in dental plaque are necessary for the development of periodontitis but this etiology alone does not explain all its clinicopathologic features. Researchers have proven the role of certain viruses like herpes virus in periodontal disease which implies that other viral agents like human papilloma virus may also be involved. Aims: This cross-sectional study was conducted to determine the proportion of patients with human papilloma virus (HPV-16) in marginal periodontium by analyzing DNA from the gingival tissue sample and to understand its association with periodontitis. Settings and Design: 102 systemically healthy patients between the age group of 15 and 70 years reporting to the Department of Periodontology who required surgical intervention (flap surgery for patients with periodontitis and crown lengthening for healthy patients) with internal bevel gingivectomy were selected. Materials and Methods: After scaling and root planning, gingival tissue was collected during the respective surgical procedure. DNA was isolated and amplified using specific primers for HPV-16 by polymerase chain reaction (PCR). The amplified products were checked by agarose gel electrophoresis. Results: No HPV DNA was detected in the 102 samples analyzed. Conclusion: Marginal periodontium does not contain HPV in this study population and hence there was no association between HPV and periodontitis.

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