Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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REVIEW ARTICLE
Year : 2013  |  Volume : 17  |  Issue : 3  |  Page : 292-301

Molecular mechanisms involved in the bidirectional relationship between diabetes mellitus and periodontal disease


Department of Periodontics and Oral Implantology, SGT Dental College, Hospital and Research Institute, Gurgaon, Haryana, India

Correspondence Address:
Shailly Luthra
Flat No. 1004, Antariksh Greens, Doordarshan Welfare Organization, Plot No. 8, Sector 45, Gurgaon - 3, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.115642

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Both diabetes and periodontitis are chronic diseases. Diabetes has many adverse effects on the periodontium, and conversely periodontitis may have deleterious effects further aggravating the condition in diabetics. The potential common pathophysiologic pathways include those associated with inflammation, altered host responses, altered tissue homeostasis, and insulin resistance. This review examines the relationship that exists between periodontal diseases and diabetes mellitus with a focus on potential common pathophysiologic mechanisms.


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