Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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ORIGINAL ARTICLE
Year : 2010  |  Volume : 14  |  Issue : 2  |  Page : 109-113

Role of salivary leukocyte protease inhibitor in periodontal disease progression


1 Department of Oral Pathology, K. M. Shah Dental College and Hospital, Sumandeep Vidhyapeeth University, Vadodara, Gujarat, India
2 Department of Oral Pathology, KLE's Vishwanath Katti Institute of Dental Sciences, KLE University, Belgaum, India

Correspondence Address:
Deepak Pateel
Department of Oral Pathology, K. M. Shah Dental College and Hospital, Sumandeep Vidhyapeeth University, Vadodara
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.70830

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Context: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity. The association between the proteases and periodontitis is well established, but not many studies have been carried out to know the role played by a protease inhibitor like salivary leukocyte protease inhibitor (SLPI) in periodontitis. Aim: The aim of the present study was to correlate SLPI with periodontitis. Settings and Design: Case-control study. Materials and Methods: Seventy-five clinically confirmed cases of periodontitis and 20 controls were included in the study. A detailed case history and periodontal index (PI) were recorded. Two milliliters of unstimulated saliva samples was obtained and subjected to quantification of SLPI leaves using SLPI in enzyme-linked immunosorbent assay (ELISA) kit. Based on the periodontal index score of the individuals, the cases and controls were divided into groups A, B and C, and the obtained SLPI levels were compared among the groups. Statistical Analysis: Mann-Whitney U test and correlation coefficient test. Results: The results showed that in the initial stages of periodontitis there is a tendency of SLPI levels to be raised. The SLPI levels were found to be reduced in the terminal stages of periodontitis. Conclusion: It appears that SLPI accumulates in the local environment, at least in the initial stages of the periodontal disease, probably to inhibit the action of increased elastic activity.


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