Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 13  |  Issue : 2  |  Page : 75-78

Estimation of nitric oxide as an inflammatory marker in periodontitis


1 Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India
2 Department of Biochemistry, K.S. Hegde Medical Academy, Mangalore, Karnataka, India

Correspondence Address:
K B Menaka
Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Derlakatte, Mangalore - 575018
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.55842

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Nitric oxide (NO) is not only important in host defense and homeostasis but it is also regarded as harmful and has been implicated in the pathogenesis of a wide variety of inflammatory and autoimmune diseases. The presence of NO in periodontal disease may reflect the participation of an additional mediator of bone resorption responsible for disease progression. The aim of this study was to assess the level of NO in serum in chronic periodontitis, and correlate these levels with the severity of periodontal disease. Sixty subjects participated in the study and were divided into two groups. NO levels were assayed by measuring the accumulation of stable oxidative metabolite, nitrite with Griess reaction. Results showed subjects with periodontitis had significantly high nitrite in serum than healthy subjects. NO production is increased in periodontal disease, this will enable us to understand its role in disease progression and selective inhibition of NO may be of therapeutic utility in limiting the progression of periodontitis.


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